Yes, CBD oil does work! CBD oil works in conjunction with the endocannabinoid system. Because CBD is a cannabinoid, it helps supplement the bodys natural cannabinoids, strengthening the endocannabinoid system. In other words, the endocannabinoid system is a vast system of cannabinoid receptors. Furthermore, the body itself produces its own natural cannabinoids. CBD oil or cannabidiol, in general, is known as a phytocannabinoid (plant-based cannabinoid) that can help to supplement the endocannabinoid system (ECS).